
SEL24-B489 hydrochloride
CAS No. ——
SEL24-B489 hydrochloride( SEL24 )
Catalog No. M16975 CAS No. ——
SEL24-B489 (SEL24) is a potent, dual PIM and FLT3-ITD inhibitor.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
100MG | Get Quote | Get Quote |
![]() ![]() |
200MG | Get Quote | Get Quote |
![]() ![]() |
500MG | Get Quote | Get Quote |
![]() ![]() |
1G | Get Quote | Get Quote |
![]() ![]() |
Biological Information
-
Product NameSEL24-B489 hydrochloride
-
NoteResearch use only, not for human use.
-
Brief DescriptionSEL24-B489 (SEL24) is a potent, dual PIM and FLT3-ITD inhibitor.
-
DescriptionSEL24-B489 (SEL24) is a potent, dual PIM and FLT3-ITD inhibitor with Kd of 2/2/3 nM for PIM1/2/3, Kd of 160/16 nM for FLT3-WT/FLT3-ITD, respectively; exhibits significantly broader on-target activity in AML cell lines (MV-4-11 GI50=20 nM) and primary AML blasts than selective FLT3-ITD or PIM inhibitors, decreases viability of AML cells with FLT3-TKD mutations associated with resistance to selective FLT3-ITD inhibitors; inhibits the growth of a broad panel of AML cell lines in xenograft models.Blood Cancer Phase 2 Clinical.
-
In Vitro——
-
In Vivo——
-
SynonymsSEL24
-
PathwayJAK/STAT Signaling
-
TargetPim
-
RecptorPim
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number——
-
Formula Weight482.601
-
Molecular FormulaC15H19Br2ClN4O2
-
Purity>98% (HPLC)
-
Solubility——
-
SMILES——
-
Chemical Name5,6-dibromo-4-nitro-2-(piperidin-4-yl)-1-(propan-2-yl)-1H-1,3-benzodiazole hydrochloride
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Czardybon W, et al. Oncotarget. 2018 Mar 30;9(24):16917-16931.
2. Bia?opiotrowicz E, et al. J Cell Mol Med. 2018 Apr 17. doi: 10.1111/jcmm.13632.
3. Szyd?owski M, et al. Blood. 2017 Sep 21;130(12):1418-1429.
molnova catalog



related products
-
Pim-1/2 kinase inhib...
Pim-1/2 Kinase Inhibitor 1, an orally active inhibitor, impedes the action of Pim kinases by preventing their ability to phosphorylate peptides.
-
LGB-321
LGB-321 (LGB321) is a potent and specific pan-Pim inhibitor with Ki of 1/2.1/0.8 pM for Pim1/2/3, respectively.
-
GDC-0339
GDC-0339 is a novel small molecule pan-Pim kinase inhibitor that was discovered as a potential treatment for multiple myeloma.