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SEL24-B489 hydrochloride
CAS No. ——
SEL24-B489 hydrochloride( SEL24 )
Catalog No. M16975 CAS No. ——
SEL24-B489 (SEL24) is a potent, dual PIM and FLT3-ITD inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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| 500MG | Get Quote | Get Quote |
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Biological Information
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Product NameSEL24-B489 hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionSEL24-B489 (SEL24) is a potent, dual PIM and FLT3-ITD inhibitor.
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DescriptionSEL24-B489 (SEL24) is a potent, dual PIM and FLT3-ITD inhibitor with Kd of 2/2/3 nM for PIM1/2/3, Kd of 160/16 nM for FLT3-WT/FLT3-ITD, respectively; exhibits significantly broader on-target activity in AML cell lines (MV-4-11 GI50=20 nM) and primary AML blasts than selective FLT3-ITD or PIM inhibitors, decreases viability of AML cells with FLT3-TKD mutations associated with resistance to selective FLT3-ITD inhibitors; inhibits the growth of a broad panel of AML cell lines in xenograft models.Blood Cancer Phase 2 Clinical.
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In Vitro——
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In Vivo——
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SynonymsSEL24
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PathwayJAK/STAT Signaling
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TargetPim
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RecptorPim
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Research Area——
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Indication——
Chemical Information
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CAS Number——
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Formula Weight482.601
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Molecular FormulaC15H19Br2ClN4O2
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name5,6-dibromo-4-nitro-2-(piperidin-4-yl)-1-(propan-2-yl)-1H-1,3-benzodiazole hydrochloride
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Czardybon W, et al. Oncotarget. 2018 Mar 30;9(24):16917-16931.
2. Bia?opiotrowicz E, et al. J Cell Mol Med. 2018 Apr 17. doi: 10.1111/jcmm.13632.
3. Szyd?owski M, et al. Blood. 2017 Sep 21;130(12):1418-1429.
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