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SEL24-B489 hydrochloride

CAS No. ——

SEL24-B489 hydrochloride( SEL24 )

Catalog No. M16975 CAS No. ——

SEL24-B489 (SEL24) is a potent, dual PIM and FLT3-ITD inhibitor.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    SEL24-B489 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    SEL24-B489 (SEL24) is a potent, dual PIM and FLT3-ITD inhibitor.
  • Description
    SEL24-B489 (SEL24) is a potent, dual PIM and FLT3-ITD inhibitor with Kd of 2/2/3 nM for PIM1/2/3, Kd of 160/16 nM for FLT3-WT/FLT3-ITD, respectively; exhibits significantly broader on-target activity in AML cell lines (MV-4-11 GI50=20 nM) and primary AML blasts than selective FLT3-ITD or PIM inhibitors, decreases viability of AML cells with FLT3-TKD mutations associated with resistance to selective FLT3-ITD inhibitors; inhibits the growth of a broad panel of AML cell lines in xenograft models.Blood Cancer Phase 2 Clinical.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    SEL24
  • Pathway
    JAK/STAT Signaling
  • Target
    Pim
  • Recptor
    Pim
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    ——
  • Formula Weight
    482.601
  • Molecular Formula
    C15H19Br2ClN4O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    5,6-dibromo-4-nitro-2-(piperidin-4-yl)-1-(propan-2-yl)-1H-1,3-benzodiazole hydrochloride

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Czardybon W, et al. Oncotarget. 2018 Mar 30;9(24):16917-16931. 2. Bia?opiotrowicz E, et al. J Cell Mol Med. 2018 Apr 17. doi: 10.1111/jcmm.13632. 3. Szyd?owski M, et al. Blood. 2017 Sep 21;130(12):1418-1429.
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